Lodonal™

 

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LDN Medicine and Medication

 

Lodonal (LDN) works by boosting levels of endorphins (peptides produced in the brain and adrenal glands) that are best known for relieving pain and enhancing your sense of well-being. Endorphins are responsible for the “runner’s high” brought on by strenuous exercise. These natural peptides are also powerful modulators of the immune system.

 

Naltrexone has been used in 50 mg doses for decades to help patients recover from addiction to alcohol, heroin and other opiate drugs. However, more than 20 years ago it was discovered that very small doses of this drug—3 to 4.5 mg—have profound effects on the immune system.

 

HOW DOES LOW-DOSE NALTREXONE WORK?

 

“Low-dose naltrexone (Lodonal or LDN) is a safe, inexpensive, yet underused drug that is extremely beneficial for people with conditions marked by immune system dysfunction.

 

 

“LDN Science” explains how it works.

 

When you take Lodonal at bedtime, it attaches to opioid receptors in the brain and in all types of immune cells, which temporarily blocks endorphins from attaching to them. This signals your body to increase endorphin production. The increased endorphin production helps orchestrate the activity of stem cells, macrophages, natural killer cells, T and B cells and other immune cells.

 

It also prevents immune system overactivity, which is the crux of autoimmune disorders, and blunts the release of inflammatory and neurotoxic chemicals in the brain.

 

WHAT DOES TREATMENT WITH LDN INVOLVE?

 

Lodonal requires a prescription and is available only from compounding pharmacies. (Regular pharmacies typically carry only 50 mg capsules.) The suggested dose is 3–4.5 mg per day, taken orally at bedtime.

 

The only contraindication is narcotic drugs. Low-dose naltrexone blocks the effects of narcotics and could cause withdrawal symptoms, so it should be started only after those drugs are completely out of your system.

“Lodonal is safe and well tolerated. You may have vivid dreams at first, but sleep disturbances are rare. To avoid this, start with a dose of 1.5 mg and build up slowly over two months.”

 

– Dr. Julian Whitaker

 

WHAT CONDITIONS IS LDN GOOD FOR?

 

Low dose naltrexone offers some possibility of treatment usefulness through its ability to increase serum endorphin levels to reduce inflammation and gliosis and scarring of motor neuron cells. We have so far treated 6 patients with ALS with LDN. All are men in advanced stages of the disease. The longest of the patients has been on LDN for 9 months and the patient on LDN for the shortest time is2 months. All have shown arrest of disease progression. Five of the six have shown at least a 20% improvement in the forced vital capacity, the breathing test that measures function of the diaphragm. Four have shown modest improvement in ability to move their arms and hands and the ability to hold their head up with neck muscles. It is difficult to predict whether further improvement will occur but it is likely that only the most recently lost functions will improve because of the permanent scarring and loss of nerve tracks and neurons involved in the disease. The LDN however does appear to arrest disease progression in all of the cases so far leading to the hope that with earlier diagnosis ALS associated disability could be markedly reduced.

A progressive mental deterioration that can occur in middle or old age, due to generalized degeneration of the brain. It is the most common cause of premature senility.

The only treatments available for Alzheimer’s Disease represent modest and time-limited benefit using cholinergic agents and acetyl choline precursors since the parts of the brain most damaged in the disease use acetyl choline as their primary neurotransmitter. Two small recent studies with nonsteroidal anti-inflammatory drugs suggest that reducing inflammation and the subsequent neural degeneration in the brain may have some benefit in slowing disease progression. Because of the effects of LDN in inducing endorphin production which in turn reduces the inflammatory response we have treated 3 patients with Alzheimer’s disease starting 3 years ago. One patient started 2 years ago and one 18 months ago. All 3 were in their 50’s or early 60’s and had significant impairment in recall and recent memory (short-term memory) but had not yet developed seizures, slurred speech or neglect of dress or social behavior. In all 3 cases, disease progression was stopped by LDN with each case showing modest improvement in recall and recent memory, reversing the loss of function occurring in the preceding 3 to 6 months. Thus the data so far indicate that LDN can arrest the progression of Alzheimer’s disease. Because of the similarities of Pick’s Disease in neuropathology and neurophysiology with those with Alzheimer’s including the same kind of inflammation followed by scarring in the brain, Pick’s Disease should respond as well as Alzheimer’s to LDN.

An inflammatory disease that can cause some of the vertebrae in your spine to fuse together. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it may be difficult to breathe deeply.

Ankylosing spondylitis affects men more often than women. Signs and symptoms of ankylosing spondylitis typically begin in early adulthood. Inflammation also can occur in other parts of your body — most commonly, your eyes.

To delay, stop or retard the aging process. Our bodies are made of cells, and aging occurs when there is cell death. As an infant, child and young adult, our body’s cells are strong, resilient and can make new cells. As the years advance, our body’s ability to generate new cells diminishes, cell death occurs, and the aging process ensues.

A serious genetic autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. It is estimated to affect 1 in 100 people worldwide. Two and one-half million Americans are undiagnosed and are at risk for long-term health complications

Therapy that is given in addition to the primary, main, or initial therapy to maximize its effectiveness. As an adjuvant agent modifies the effect of another agent, so adjuvant therapy modifies other therapy. The surgeriesand complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments.

A complicated disorder characterized by extreme fatigue that can’t be explained by any underlying medical condition. The fatigue may worsen with physical or mental activity, but doesn’t improve with rest. Chronic fatigue syndrome has also been called myalgic encephalomyelitis (ME) and, more recently, systemic exertion intolerance disease (SEID). Although CFS/ME and SEID share the same major symptom of chronic fatigue, there is variation between the definitions of these disorders. The symptom of chronic fatigue also may arise from more than one underlying condition.

Crohn’s most commonly affects the end of the small bowel (the ileum) and the beginning of the colon, but it may affect any part of the gastrointestinal (GI) tract, from the mouth to the anus. Ulcerative colitis is limited to the colon, also called the large intestine.When reading about inflammatory bowel diseases, it is important to know that Crohn’s disease is not the same thing as ulcerative colitis, another type of IBD. The symptoms of these two illnesses are quite similar, but the areas affected in the gastrointestinal tract (GI tract) are different. Crohn’s disease can also affect the entire thickness of the bowel wall, while ulcerative colitis only involves the innermost lining of the colon. Finally, in Crohn’s disease, the inflammation of the intestine can “skip”– leaving normal areas in between patches of diseased intestine. In ulcerative colitis this does not occur.

It happens when tissue normally found inside the uterus grows in other parts of the body. It may attach to the ovaries, fallopian tubes, the exterior of the uterus, the bowel, or other internal parts. As hormones change during the menstrual cycle, this tissue breaks down and may cause painful adhesions, or scar tissue. More than 5.5 million American women have symptoms of endometriosis

A common and complex chronic pain disorder that causes widespread pain and tenderness to touch that may occur body wide or migrate over the body. Along with other symptoms, pain and tenderness wax and wane over time.  Fibromyalgia (FM) affects people physically, mentally and socially. Approximately 10 million Americans (2-4%) have FM with a ratio of about 8 to 2, women over men. It occurs in people of all ages, including children. The literal translation of the word fibromyalgia is pain in the muscles, ligaments and tendons.

Represents a group of intestinal disorders that cause prolonged inflammation of the digestive tract. The digestive tract is composed of the mouth, esophagus, stomach, small intestine, and large intestine. It’s responsible for breaking down food, extracting the nutrients, and removing any unusable material and waste products. Inflammation anywhere along the digestive tract disrupts this normal process. IBD can be very painful and disruptive, and in some cases, may even be life-threatening. Many diseases are included in this IBD umbrella term. The two most common diseases are ulcerative colitis and Crohn’s disease. Crohn’s disease can cause inflammation in any part of the digestive tract. However, it mostly affects the tail end of the small intestine. Ulcerative colitis involves inflammation of the large intestine.

A chronic, autoimmune disease that can damage any part of the body (skin, joints, and/or organs inside the body). Chronic means that the signs and symptoms tend to last longer than six weeks and often for many years. In lupus, something goes wrong with your immune system, which is the part of the body that fights off viruses, bacteria, and germs (“foreign invaders,” like the flu). Normally our immune system produces proteins called antibodies that protect the body from these invaders. Autoimmune means your immune system cannot tell the difference between these foreign invaders and your body’s healthy tissues (“auto” means “self”) and creates autoantibodies that attack and destroy healthy tissue. These autoantibodies cause inflammation, pain, and damage in various parts of the body.

MS is a long-lasting disease that can affect your brain, spinal cord, and the optic nerves in your eyes. It can cause problems with vision, balance, muscle control, and other basic body functions. The effects are often different for everyone who has the disease. Some people have mild symptoms and don’t need treatment. MS happens when your immune system attacks a fatty material called myelin, which wraps around your nerve fibers to protect them. Without this outer shell, your nerves become damaged. Scar tissue may form.

“The use of low doses of naltrexone for the treatment of multiple sclerosis (MS) enjoys a worldwide following amongst MS patients. There is overwhelming anecdotal evidence, that in low doses naltrexone not only prevents relapses in MS but also reduces the progression of the disease. It is proposed that naltrexone acts by reducing apoptosis of oligodendrocytes. It does this by reducing inducible nitric oxide synthase activity. This results in a decrease in the formation of peroxynitrites, which in turn prevent the inhibition of the glutamate transporters” – Low dose naltrexone therapy in multiple sclerosis.

A chronic and progressive movement disorder, meaning that symptoms continue and worsen over time. Nearly one million people in the US are living with Parkinson’s disease. The cause is unknown, and although there is presently no cure, there are treatment options such as medication and surgery to manage its symptoms. Parkinson’s involves the malfunction and death of vital nerve cells in the brain, called neurons. Parkinson’s primarily affects neurons in an area of the brain called the substantia nigra. Some of these dying neurons produce dopamine, a chemical that sends messages to the part of the brain that controls movement and coordination. As PD progresses, the amount of dopamine produced in the brain decreases, leaving a person unable to control movement normally.

It’s easy to think of psoriasis as just a “skin condition.” But psoriasis actually starts underneath the skin. It is a chronic (long-lasting) disease of the immune system that can range from mild to severe. Like most chronic illnesses, psoriasis may be associated with other health conditions such as psoriatic arthritis, Type 2 diabetes, and cardiovascular disease.

Arthritis means inflammation in a joint. That inflammationcauses redness, warmth, swelling, and pain within the joint. Affects joints on both sides of the body, such as both hands, both wrists, or both knees. This symmetry helps to set it apart from other types of arthritis. RA can also affect the skin, eyes, lungs, heart, blood, or nerves.

It’s an inflammatory disease that can affect almost any organ in the body. It causes heightened immunity, which means that a person’s immune system, which normally protects the body from infection and disease, overreacts, resulting in damage to the body’s own tissues. The classic feature of sarcoidosis is the formation of granulomas, microscopic clumps of inflammatory cells that group together (and look like granules, hence the name). When too many of these clumps form in an organ they can interfere with how that organ functions.

Or systemic sclerosis, a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases.

A chronic disease of the large intestine, also known as the colon, in which the lining of the colon becomes inflamed and develops tiny open sores, or ulcers, that produce pus and mucous. The combination of inflammation and ulceration can cause abdominal discomfort and frequent emptying of the colon. Ulcerative colitis is the result of an abnormal response by your body’s immune system. Normally, the cells and proteins that make up the immune system protect you from infection. In people with IBD, however, the immune system mistakes food, bacteria, and other materials in the intestine for foreign or invading substances. When this happens, the body sends white blood cells into the lining of the intestines, where they produce chronic inflammation and ulcerations.

 

NAFDAC Approval

 

Immune Therapeutics, Inc. (OTCQB:IMUN) (the “Company”), a clinical-stage biotech company providing immunotherapy solutions for the treatment of autoimmune disease and cancer with a focus on emerging nations, today announced that Nigeria’s National Agency for Food and Drug Administration and Control (NAFDAC) has approved its patented Lodonal as an over the counter, non-toxic adjunct therapy in the treatment of HIV/AIDS and immune system regulator.

 

The receipt of NAFDAC’s approval will enable the Company’s distribution partner, AHAR Pharma, and GB Pharma Holdings, to launch a nationwide marketing and sales program that is expected to generate new and significant revenue channels for the Company. The Company believes that this new sales revenue places it on-track towards achieving profitability and significant future revenue and earnings growth.

 

Phase III Trails: A number of phase I and phase II trials have shown Lodonal to benefit in the treatment of HIV/AIDS, cancer and autoimmune diseases. Where there is continued research with Lodonal until recently there was no one Biotech Company interested in completing phase III trials with Lodonal. The body of research is growing rapidly, along with clinical experience and Lodonal certainly seems to work for many people. Which is why one small company Immune Therapeutics has moved forward with acquiring all of the patents and clinical work surrounding LDN so that they can obtain regulatory approval for Lodonal in emerging nations while Cytocom is working with the FDA and EMA for Lodonal approval in the United States and EU.

 

 

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